According to the Global Program for Elimination of Lymphatic Filariasis (GPELF), anti-Wolbachial chemotherapy is used as an alternative strategy for controlling lymphatic filariasis. In bancroftian and brugian filariasis, 3 (Turner et al., 2006), 4 (Debrah et al., 2007), 6 (Hoerauf et al., 2003; Supali et al., 2008), 8 (Taylor et al., 2005b) -week courses of treatment with 100 or 200 mg/day of doxycycline alone or in combination, has resulted in a macrofilaricidal effect, a decrease in microfilaremia, a reduction in Wolbachia copy number in the microfilariae, and an abatement in drug adverse reactions. More potent and short-term therapy of anti-Wolbachial and anti-filarial chemotherapeutic agents should be screened and identified. Tigecycline, a new class of antibiotic, glycylcycline, which has structural similarlities to the tetracycline, has been suggested to test against experimental filarial infections (Rao, 2005). Since, doxycycline has limited used in pregnant, breastfeeding women, and children children under the age of nine (Hoerauf, 2008) then, rifampicin which has anti-Wolbachial and anti-filarial activities could be used as an alternative regimen (Specht et al, 2008). In addition, the macrofilaricidal activity of human lymphatic filariasis using a combination of doxycycline and rifampicin for 3-week course has been studied so far Hoerauf, 2008).
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Nor-mai 
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4 มี.ค. 52 22:46:11
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