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ความคิดเห็นที่ 5 |
In long term (2-year) studies in rats, omeprazole (e.g. prilosec) produced a dose related increase in gastric carcinoid tumors. While avaliable endoscopic evaluations and histologic examinations of human biopsies have not detected a risk from short term (8 week) use, further research and longer follow up is needed to find out the risk of developing that kind of complication in humans.
One other concern relates to a theoretical risk of atrophy of the stomach lining because of the long-term suppression of acid secretion by stomach cells, but this has not led to complications in patients so far.
That said it should be known that proton pump inhibitors (e.g. omeprazole) drugs have now been available for about 10 years and have been used even longer in clinical research studies. To date, no severe long-term side effects have been detected. Thus, it is considered safe to take PPI medications indefinitely at this time.
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ในคนยังไม่ยืนยันนะครับ
แต่ใน หนู พบว่า เพิ่มความเสี่ยง ต่อ gastric carcinoid tumor
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7thHelL  
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| เขียนเมื่อ |
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10 พ.ย. 52 19:14:26
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